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مجموعة البنسلين penicillins

اقرأ أيضًا: المضادات الحيوية 1

 

و يتضح من تركيبته أنه يحتوي على المجموعة (β-Lactam) و هي المنطقة الفاعلة في تركيبة جزيء البنسلين، لذلك يندرج تحت تصنيف “المضادات الحيوية بيتا-لاكتام”

مكان عمله في البكتيريا: يعمل البنسلين مثل باقي المضادات الحيوية المحتوية على بيتا-لاكتام بتثبيط تصنيع بعض مكونات الجدار الخلوي للبكتيريا, وتعتبر مجموعة البنسلين من المضادات الحيوية القاتلة للبكتيريا Bactericidal .

مشتقات البنسلين:

1-بنسلين جي penicillin GBenzylpenicillin) :

-أول مضاد حيوي تم اكتشافه في العالم

 -يعطى عن طريق العضل، أو الوريد (IV, IM)، و لا يستخدم عبر الفم لتأثره بإفرازات المعدة

- يعتبر من المضادات الحيوية التي تعمل بطريقة قتل البكتيريا (bactericidal)

- يمكن أن يصاب المريض بحساسية من البنسلين جي (قد تسبب موته خلال دقائق!) لذلك يجب إجراء اختبار حساسية بحقن كمية بسيطة منه أسفل الجلد و ملاحظة النتيجة

- في حالة حدثت حساسية من حقن بنسلين جي للمريض نستخدم السيترويد أو الأبينفرين (أدرينالين)

- يستخدم هذا النوع من البنسلين إلى الآن فقط مع مرضى الزهري  (Syphilis)أو الغرغرينا من نوع غاز قنقرين ( (Gas Gangrene

2-بنسلين في (penicillin V) :

يتميز بأن الـ MIC  لديه مرتفع جدًا، لذلك إما أن يتم استخدامه بكميات كبيرة أو لفترات طويلة حتى يصل للتركيز المطلوب ليؤدي مفعوله.

أصبح يستخدم للحالات البسيطة و غير الحرجة، بحيث يصرف للمريض جرعات قليلة لكن لفترات طويلة.

ما هو الـ MIC :

لكل دواء حدّ يسمى Minimal inhibitory concentration و هو الحدّ الأقل من التركيز القادر على إيقاف و تثبيط البكتيريا، و يختصر (MIC) . و حّد آخر يسمى Maximum inhibitory concentration وهو الحدّ الأكثر من تركيز الدواء غير المضر بصحة المريض.

 قبل وصول تركيز الدواء للـMIC يكون الدواء غير مفيد في محاربة البكتيريا، بعد تجاوز تركيز الدواء الـ Maximum inhibitory concentration يصبح الدواء ضار بصحة المريض.

فالمسافة ما بين MIC  و Maximum inhibitory concentration تسمى therapeutic index   

كلما كانت مساحة الثيرابيوتك اندكس واسعة كان أفضل، و إذا كانت مساحة الثيرابوتك اندكس ضيقة يحتسب هذا كأحد سلبيات الدواء. لماذا؟

لأن الدواء الذي تكون مساحة الثيرابوتك اندكس فيه ضيقة يتطلب دقة شديدة في الجرعات، فأي زيادة البسيطة عن الـ MIC  تسبب وصول الجرعة إلى مستوى Maximum فيحصل للمريض تسمم بالدواء.

مصدر الصورة: http://pharmacologycorner.com/

بعد أن وجدنا أن البنسلين في غير فعّال لأنه يحتاج إلى جرعات كبيرة أو إلى فترات طويلة من الاستخدام، تم اكتشاف مضاد حيوي جديد وهو الـ أمبسلين ampicillin

3- أمبسلين (ampicillin):

-يتميز بأن الثيرابيوتك اندكس (therapeutic index) لديه كبير

-يصلح للإستخدام الفموي (Orally)

  -إضافة إلى أن الـMIC  لديه منخفض

 و هذه (ثلاث إيجابيات!)

تم تطوير الأمبيسلين بعد أن تغلبت البكتيريا عليه، و بإضافة حمض الكلافولانيك (Clavulinic acid) إلى الأمبيسلين ينتج لنا المضاد الحيوي الجديد (ougmentin)

Clavulinic acid + ampicllin = ougmentin

4- ميتاسيلين  (metha-cillin)

ممتاز في مقاومة البكتيريا التي تغلبت على باقي المضادات من مجموعة البنسلين (ستاف بكتيريا)، مع ذلك ظهرت مجموعة من البكتيريا لديها القدرة على التغلب عليه و عرفت بـ methicillin resistance S.aureus و تختصر MRSA، و هي من أنواع البكتيريا الخطيرة و التي تسبب مشاكل قاتلة لأصحاب المناعة الضعيفة كالمرضى و المواليد و كبار السن.

و كانت مشكلة الميتاسيلين هي أنه يسبب للمريض مشاكل خطيرة في القناة البولية Renal Problem فتم تطوير تركيبته للتخلص من هذه الأثار الجانبية السيئة و أنتجنا اشتقاقًا منه:

1- oxacillin

2- Dicloxacillin

3- Cloxacillin

4- Nafcillin

و انحصر استخدام الميتاسيلين فقط في المختبرات لاختبار نوع البكتيريا، فإذا كان لدينا مري البكتيريا من نوع “ستاف” نجربها مع الميتاسيلين: لو قضى عليها نعرف بأنها MSSA  والمشتقات الأربعة المذكورة أعلاه ناجحة للاستخدام، و لو لم تنفع نعرف بأن البكتيريا من نوع MRSA و نعمل بالاحتياطات اللازمة أمام هذا النوع الخطير من البكتيريا.

MSSA = Methicillin-Sensitive Staphylococcus aureus

من مشتقات البنسلين أيضًا:

Carbenicillin

Piperacillin

Ticarcillin

المراجع /

محاضرة الدكتور عبدالناصر الهلالي

 Chemotherapy For L6 Pharmacy By Dr. Mohamed Mostafa Elbader

البنسلين : د. منير حميد راجح 

 penicillin

penicillin

MRSA

عدد التعليقات 4,993 حتى الان.

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